Pulmonary hypertension means the high blood pressure of lung arteries and the right heart. It is a serious health condition, which may cause failure of right heart and immature death to both, adults and infants. The occurrences, causes, classifications, symptoms and diagnosis methods have been explained in Pulmonary Hypertension. Now we are trying to discuss about some common medications to treat pulmonary hypertension. Although it is difficult to find out the effective treatments for patients. According to WHO (world health organization), pulmonary hypertension is grouped under five classes and the treatments are different for each type.
Treatments for pulmonary hypertension
- Oxygen therapy: common phenomenon of pulmonary hypertension is physical weakness, fatigue and dizziness, because of oxygen deficiency in blood. It occurs in the people having sleep apnea or living at a high altitude. In that case, if the patient is treated by pure oxygen, he/she will get relief. Some patients are treated with a constant oxygen therapy, prescribed by doctors.
- Nitric oxide therapy: nitric oxide is a vasodilator, which dilates or relaxes narrowed blood vessel. Inner space of the arteries become larger and blood pressure falls down. Vasodilator give quick relief to the pulmonary hypertensive patients. Nitric oxide is given through an inhaler. Another vasodilators are epoprostenol and ilprost. The effects of both, NO and epoprostenol last for a very short time. Therefore the drug is intravenously injected continuously via a small pump that is set up on patient’s shoulder. It gives potential treatment, but has some side effects, like jaw pain, leg cramps, diarrhea, nausea and infection at the site of injection. Iloprost is given with nebulizer. This vasodilator has also some side effects, including chest pain, nausea and headache.
- Endothelin receptor antagonists: endothelin is a substance, found in the arterial wall, which is responsible for narrowing blood vessel. have reverse effects of targeted substances. If endothelin receptor antagonist is used in pulmonary hypertension, it occupies instead of endothelin and blood vessel remain relaxed. Some of the potent antagonists are Bosetan and Ambrisentan. Both of these drugs have restricted use, not given to the pregnant women. Beside this, drugs are given under complete monitoring, because both of them causes serious liver damage. You have to check the liver condition before using these drugs.